Single-cell S-value calculations for Auger-electron emitting radionuclides

Dosimetry of Auger-Electron-Emitting Radionuclides

Monte Carlo evaluation of Auger electron-emitting theragnostic radionuclides

Monte Carlo Evaluation of Auger Electron-Emitting Theranostic Radionuclides.

UNLABELLED Several radionuclides used in medical imaging emit Auger electrons, which, depending on the targeting strategy, either may be exploited for therapeutic purposes or may contribute to an unintentional mean absorbed dose burden. In this study, the virtues of 12 Auger electron-emitting radionuclides were evaluated in terms of cellular S values in concentric and eccentric cell-nucleus arr...

Cellular dosimetry of beta emitting radionuclides-antibody conjugates for radioimmunotherapy

Introduction: The choice of optimal radionuclides for radioimmunotherapy depends on several factors, especially the radionuclide and antibody. The dosimetric characteristics of a non-internalizing and an internalizing monoclonal antibody (MAb) labeled with beta emitting radionuclides were investigated. Methods: Using Geant4-DNA Monte Carlo simulation, we ...

Antibody-based cancer treatment with ultra-short range Auger electron-emitting radionuclides: dual receptor and DNA targeting strategies.

The long-heralded potential of targeted cancer treatment using monoclonal antibodies is finally being realized. Several antibodies are already used in the oncology clinic and many others are undergoing preclinical evaluation. In addition to the development of unconjugated antibodies, there is intense interest in the potential clinical use of antibodies as vehicles for targeting cytotoxic agents...